Nano Silica Phosphoric Acid: An Efficient Catalyst for the One- Pot Synthesis of 1, 2, 4, 5-Tetrasubstituted Imidazoles

Authors

A. Bamoniri Deprtment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R. Iran.

B. F. Mirjalili Department of Chemistry, College of Science, Yazd University, I. R. Iran .

S. Nazemian Deprtment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R. Iran.

Abstract:

Two simple protocols for the synthesis of 1, 2, 4, 5- tetrasubstitutedimidazoles using nano-SPA as a reusable, eco- friendly, inexpensive, and efficient catalyst are reported. Short reaction times, high yields, scale-up and easy workup are the advantages of these protocols.

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